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This is the "Clinical Research" page of the "Welcome to Toronto Health Economics and Technology Assessment Collaborative" guide.
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Welcome to Toronto Health Economics and Technology Assessment Collaborative  

Last Updated: Oct 12, 2017 URL: http://theta.utoronto.ca/HomePage Print Guide

Clinical Research Print Page
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Biostatistics

THETA research activities include novel application of existing Biostatistics and Epidemiology methods or development of new ones in effort to facilitate all phases of prospective or retrospective studies for generating and strengthen clinical evidence for HTA. Examples include designing and analyzing pragmatic stepped wedge design trials, measuring the impact of treatment uptake increase on mortality and others.

Team

Nicholas Mitsakakis, MSc, PhD

Lusine Abrahamyan, MD, MPH, PhD

Petros Pechlivanoglou PhD

Ba' Pham, MSc, PhD

Eleanor Pullenayegum, PhD

George Tomlinson, MSc, PhD

Andrew Willan, MSc, PhD

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Field Evaluations

New technologies and drugs are reaching the market at an astounding rate, creating extreme pressures within our publicly-funded health system.

The Ontario Ministry of Health and Long-Term Care relies on the Ontario Health Technology Advisory Committee (OHTAC) and its Medical Advisory Secretariat (MAS) to provide evidence-based policy advice on the adoption of new health technologies

THETA provides health policy analysts at MAS with a wide variety of methodological and technical support, including: field evaluations, comprehensive evidence synthesis and economic evaluation. Technical support is provided in complex decision modeling, Bayesian methods, utility assessment, and the use of administrative data for health technology assessment.|

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Health Utility and Quality of Life

Health utility and quality of life provide researchers and decision-makers with the ability to measure improvements in health outcomes beyond mortality figures. These measures are significant in health technology assessments because they also capture issues of quality of life from the perspective of the patient.

Health-related quality of life may be measured using non-preference or preference-based approaches. Preference-based approaches measure quality of life using utility, a global measure of health status, scaled from 0-1. Utility is used to calculate quality-adjusted life years (QALY) in cost-effectiveness analyses and decision models.

  • THETA investigators have particular interest in:
  • developing population-based reference values for utilities
  • measuring disease/condition-specific utilities
  • developing and assessing quality of life and health outcome scales using classical and modern measurement methods, including Rasch and Mokken analyses
  • exploring the relationship between patient and surrogate values/utilities, and
  • measuring utilities in special populations (e.g., patients with HIV, Hepatitis C and Alzheimer's Disease, and children).

Team

Shabbir Alibhai, MD, MSc, FRCPC

Ahmed M. Bayoumi, MD, MSc, FRCPC

Murray Krahn, MD, MSc, FRCPC

Linda D MacKeigan, BSc, Phm, PhD

Gary Naglie, MD, FRCPC

George Tomlinson, MSc, PhD

Wendy Ungar, MSc, PhD

Gabrielle van der Velde, DC, PhD, Clinical Epidemiologist

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  • OUR PARTNERS
  • Leslie Dan Faculty of Pharmacy at the University of Toronto
  • Institute of Health Policy, Management and Evaluation (IHPME)
  • UHN - Toronto General Hospital
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