Our Mission & VisionHistory of THETATHETA Staff & CommunityTHETA News ArchiveTHETA Events ArchiveContact Us
Health Modelling and Health EconomicsClinical ResearchHealth Policy and Ethics
Current StudiesCompleted Studies
THETA Quarterly NewsletterReportsPublicationsPresentationsTHETA KT Day, Symposium
and other KT events
Introduction to R for health researchersDecision Modelling Using RHealth Technology Assessment for Decision MakingHTA CoursesClinEpi RoundsTHETA Rounds
HTA OrganizationsHTA ConferencesHTA Resources & Tools
Bin Wu ProfileChristelle Moneypenny ProfileMurray Krahn ProfileValeria Rac ProfileLusine Abrahamyan ProfileJoanna Bielecki ProfileSteven Carcone ProfileBrian Chan ProfileSuzanne Chung ProfileIris Fan ProfileOlga Gajic-Veljanoski ProfileGemma Hunting ProfileMildred Lim ProfileKaren Liu ProfileNicholas Mitsakakis ProfilePetros Pechlivanoglou ProfileYelena Petrosyan ProfileBa' Pham ProfileWelson Ryan ProfileYeva Sahakyan ProfileNida Shahid ProfileAleksandra Stanimirovic ProfileGabrielle Van Der Velde ProfileJosephine Wong ProfileWilliam Wong ProfileShawn Xie ProfileMike Paulden ProfileLouise Lemieux-Charles ProfileSarah Bermingham ProfileShabbir Alibhai ProfileAmir Azarpazhooh ProfileAhmed M. Bayoumi ProfileChaim Bell ProfileJoseph Beyene ProfileYvonne Bombard ProfileHeather Boon ProfileAnn-Sylvia Brooker ProfileSuzanne Cadarette ProfileJoseph Cafazzo ProfileWendong Chen ProfilePeter Coyte ProfilePeter Cram ProfileTony Culyer ProfileAllan Detsky ProfileRobert Fowler ProfileJennifer Gibson ProfilePaul Grootendorst ProfileJeffrey S. Hoch ProfileAudrey Laporte ProfileLouise Lemieux-Charles ProfileLinda D. Mackeigan ProfileMuhammad Mamdani ProfileEleanor Pullenayegum ProfileFiona Miller ProfileNicole Mittmann ProfileGary Naglie ProfileBeate Sander ProfileMonica Parry ProfileJanet Parson ProfileZahava Rosenberg-Yunger ProfileHla Hla (Rosie) Thein ProfileGeorge Tomlinson ProfileWendy Ungar ProfileDavid R. Urbach ProfileHarindra Wijeysundera ProfileAndrew Willan ProfileHolly Witteman ProfileWalter Wodchis ProfileGreg Zaric ProfileMerrick Zwarenstein ProfileSarah Bermingham ProfileSavtaj Brar ProfileKaren E. Bremner ProfileDavid Chartash ProfileMaggie Hong Chen ProfileWarren Chin ProfileKuhan Perampaladas ProfileFarah Farahati ProfileKalyani Baldota ProfileRebecca Hancock-Howard ProfileLuciano Ieraci ProfileAva John-Baptiste ProfileMichele Kohli ProfileYan Yun Liu ProfileMarcio Machado ProfileClaire de Oliveira ProfileOrges Ormanidhi ProfileAndrew Pinto ProfileCharly Piwko ProfileMayvis Rebeira ProfileWilliam Witteman ProfileGloria Woo ProfileMary-Ellen Hogan ProfileNader N. Kabboul ProfileChang-Ho Lee ProfileNatasha Nanwa ProfileAmy Tawfik ProfileTroy Francis ProfileWanrudee Isaranuwatchai ProfileFarah N. Mawani ProfileBeena Vyas ProfileMohammed Alhokail ProfileKuan Liu ProfileMyrtha E. Reyna ProfileTeresa Tsui ProfileRick Maharaj ProfileYasmin Saeed ProfileArlene Nugent ProfileAustin Nam ProfileYeesha Poon ProfileAlex Haines ProfileAysegul Erman ProfileSofia Torres ProfileBeate Sander ProfileLauren Ramsay ProfileEric Nauenberg ProfileRaphael Ximenes ProfileStephen Mac ProfileMorgan Slater ProfileHeather Baltzer ProfileAndrew Mendlowitz ProfileArcturus Phoon ProfileSonia Meerai Profile
ARCC 2016 CONFERENCECAHSPR CONFERENCE 2016QUALITY INDICATORS FOR TELEHOMECARE STUDY - UPDATESMDM - 16TH BIENNIAL EUROPEAN CONFERENCECLINICAL TRIALS DAY!THETA 'S NEW HOMENEW BRU UNITRnaDx Study is recruitingMedsCheck Study – presented at OPA Annual ConferenceDr. Krahn - JAMA article and a book launchSMDM 2015 - 2ND BIENNIAL ASIA-PACIFIC CONFERENCESMDM 2016 - 38TH ANNUAL NORTH AMERICAN MEETINGSMDM 2016 Lusted Student Prize Winners from THETA communityProfessor Murray Krahn Co-Authors Chapters in "Cost-Effectiveness in Health and Medicine"THETA's Year in ReviewTHETA contributions to 2017 CADTH SymposiumDr. Murray Krahn teaches pharmacoeconomics in EthiopiaNew Study by Dr Murray Krahn and Karen Bremner Makes News at ISPOR and UHNTHETA CONTRIBUTIONS TO 2017 CAHSPR CONFERENCECLINICAL TRIALS DAY!ARCC 2017 CONFERENCETHETA PRESENTS AT 2017 IHEA WORLD CONGRESSSMDM 2017 - 39TH ANNUAL NORTH AMERICAN MEETINGDr. Slater 2017 CIHR Fellowship RecipientDr. John Baptiste article in SMDM NewsletterCongratulations to Valeria Rac's Trainees!!!Dr. Heather Baltzer offers a smile reinnervation surgery to adults
This is the "Clinical Research" page of the "Welcome to Toronto Health Economics and Technology Assessment Collaborative" guide.
Alternate Page for Screenreader Users
Skip to Page Navigation
Skip to Page Content

Welcome to Toronto Health Economics and Technology Assessment Collaborative  

Last Updated: Jan 19, 2018 URL: http://theta.utoronto.ca/HomePage Print Guide

Clinical Research Print Page


THETA research activities include novel application of existing Biostatistics and Epidemiology methods or development of new ones in effort to facilitate all phases of prospective or retrospective studies for generating and strengthen clinical evidence for HTA. Examples include designing and analyzing pragmatic stepped wedge design trials, measuring the impact of treatment uptake increase on mortality and others.


Nicholas Mitsakakis, MSc, PhD

Lusine Abrahamyan, MD, MPH, PhD

Petros Pechlivanoglou PhD

Ba' Pham, MSc, PhD

Eleanor Pullenayegum, PhD

George Tomlinson, MSc, PhD

Andrew Willan, MSc, PhD

Back to Top


Field Evaluations

New technologies and drugs are reaching the market at an astounding rate, creating extreme pressures within our publicly-funded health system.

The Ontario Ministry of Health and Long-Term Care relies on the Ontario Health Technology Advisory Committee (OHTAC) and its Medical Advisory Secretariat (MAS) to provide evidence-based policy advice on the adoption of new health technologies

THETA provides health policy analysts at MAS with a wide variety of methodological and technical support, including: field evaluations, comprehensive evidence synthesis and economic evaluation. Technical support is provided in complex decision modeling, Bayesian methods, utility assessment, and the use of administrative data for health technology assessment.|

Back to Top


Health Utility and Quality of Life

Health utility and quality of life provide researchers and decision-makers with the ability to measure improvements in health outcomes beyond mortality figures. These measures are significant in health technology assessments because they also capture issues of quality of life from the perspective of the patient.

Health-related quality of life may be measured using non-preference or preference-based approaches. Preference-based approaches measure quality of life using utility, a global measure of health status, scaled from 0-1. Utility is used to calculate quality-adjusted life years (QALY) in cost-effectiveness analyses and decision models.

  • THETA investigators have particular interest in:
  • developing population-based reference values for utilities
  • measuring disease/condition-specific utilities
  • developing and assessing quality of life and health outcome scales using classical and modern measurement methods, including Rasch and Mokken analyses
  • exploring the relationship between patient and surrogate values/utilities, and
  • measuring utilities in special populations (e.g., patients with HIV, Hepatitis C and Alzheimer's Disease, and children).


Shabbir Alibhai, MD, MSc, FRCPC

Ahmed M. Bayoumi, MD, MSc, FRCPC

Murray Krahn, MD, MSc, FRCPC

Linda D MacKeigan, BSc, Phm, PhD

Gary Naglie, MD, FRCPC

George Tomlinson, MSc, PhD

Wendy Ungar, MSc, PhD

Gabrielle van der Velde, DC, PhD, Clinical Epidemiologist

Back to Top

  • Leslie Dan Faculty of Pharmacy at the University of Toronto
  • Institute of Health Policy, Management and Evaluation (IHPME)
  • UHN - Toronto General Hospital

Loading  Loading...