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Last Updated: Aug 28, 2015 URL: http://theta.utoronto.ca/HomePage Print Guide RSS Updates

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  • Registration is now open...
  • Please see  titles posted in the News section below
  • Patient Cost Estimator - Canadian Institute for Health Information (CIHI) Tool

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  • THETA Rounds ended for current academic year
    Please check for upcoming sessions in September 2015
    Access to archived recordings of THETA Rounds is under Education ->THETA Rounds tab.
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Cost-Effectiveness of Screening Hepatitis C in Canada. - Wong WWL, Tu HA, Feld JJ, Wong T, Krahn M
Publication Date: Jan 12, 2015; Canadian Medical Association Journal (CMAJ)



Health Technology Assessment for Decision Makers course - Registration is now open...

The HTA Institute will bring together experts from a range of disciplines to provide attendees with pragmatic tools for HTA. This three-day intensive course will be useful to individuals who use HTA to make decisions relating to drugs, devices, and programs. The 2015 Health Technology Assessment Institute for Decision Makers course will be held on September 28-30, 2015, at the Leslie Dan Faculty of Pharmacy, University of Toronto.
This year the course is a product of collaboration between the Toronto Health Economics and Technology Assessment (THETA) Collaborative, Institute of Health, Policy, Management and Evaluation, University of Toronto and Leslie Dan Faculty of Pharmacy, University of Toronto. Please see more information about the course here.

THETA Rounds

THETA Rounds have ended for this academic year. The sessions will resume in September 2015.

The 14th Annual CHESG Meeting in Toronto, Ontario.

The Canadian Health Economists' Study Group organizes an annual meeting at which economists with an interest in theoretical or empirical economic analysis of health and health care related issues can try out their work before a specialist audience.
When: May 27th-28th, 2015; Location: Toronto, Ontario, Canada; Venue: The Faculty Club, 41 Willcocks St, Toronto; Registration Deadline: May 12, 2015
Posted on April 28, 2015

Canada’s Applied Research in Cancer Control Conference is in Montreal this year.

The Canadian Centre for Applied Research in Cancer Control is pleased to announce that its 4th annual ARCC conference 2015 will take place from May 24th to 25th at the Hotel Bonaventure in Montreal, Quebec. The objective of this conference is to bridge a connection between researchers and decision-makers, using health economics, services, policy and ethics research to improve cancer control and the delivery of cancer care.
The Canadian Centre for Applied Research in Cancer Control (ARCC) is an pan-Canadian research organization with a commitment to tackle on existing and emerging challenges in cancer control. Our mission is to make improvements across the cancer control spectrum through interdisciplinary leadership in health economics, services, policy and ethics, and knowledge translation.

Posted on April 24, 2015

THETA Rounds

Since 2008 THETA has been hosting  a lecture series THETA Rounds and inviting world experts to address various issues related to Health Technology Assessment field. Recordings of most sessions are available in the THETA Rounds Archive.
Topic: Statistical Prediction Models and Medical Decision Making

Lecturer: Mike Kattan, PhD, Cleveland Clinic Main Campus
Date: Friday, May 1, 2015
1:00-2:00 pm
Rm# 850, Leslie Dan Pharmacy, University of Toronto, 144 College Street



THETA Collaborative presents at the upcoming Society for Medical Decision Making (SMDM) 2015 - 37th Annual North American Meeting, October 18 - October 21, 2015 in St. Louis, Missouri.

This year’s theme: Implementation. SMDM is uniquely positioned to bring experts from a broad range of health science disciplines together to explore implementation and exchange ideas on how to improve the translation of research findings into better bedside care and health care utilization.

Congratulations to all team members whose work has been accepted for presentations at the conference.

Oral presentation

Complex Interventions for Comparative Effectiveness and Health Technology Assessment. Valeria E. Rac, MD, PhD, Lusine Abrahamyan, MD, MPH,PhD and Murray D Krahn, MD, MSc.  

Poster presentations

Impact of Telehomecare Program on monitoring parameters among COPD and HF patients. Valeria E. Rac, MD, PhD, Yeva Sahakyan, MD, MPH, Nida Shahid, Hon BSc,  Aleksandra Stanimirovic, MPH, PhD(c), Iris Fan, BA,  Welson Ryan, Petros Pechlivanglou, MSc, PhD,  Lusine Abrahamyan, MD, MPH,PhD, Murray D Krahn, MD, MSc.  

Impact of Telehomecare Program on Patients’ Quality of Life and Disease-Management Skills. Valeria E. Rac, MD, PhD, Yeva Sahakyan, MD, MPH, Nida Shahid, Hon BSc, Iris Fan, BA, Murray D Krahn, MD, MSc.  

New model of healthcare delivery - Telehomecare Program for chronic obstructive pulmonary disease (COPD) and heart failure (HF) patients in Ontario, Canada. Valeria E. Rac, MD, PhD, Yeva Sahakyan, MD, MPH, Nida Shahid, Hon BSc,  Aleksandra Stanimirovic, MPH, PhD(c), Iris Fan, BA,  Welson Ryan, Murray D Krahn, MD, MSc.

Implementation and Adoption of the Telehomecare Program for Patients with Heart Failure or Chronic Obstructive Pulmonary Disease. Gemma Hunting, BHSc(Honours), MA,  Nida Shahid, Hon BSc,  Yeva Sahakyan, MD, MPH, Iris Fan, BA,  Crystal R. Moneypenny, Hon BA, MSc (c), ,  Aleksandra Stanimirovic, MPH, PhD(c), Taylor North, Yelena Petrosyan, MD, MPH, PhD (c),  Murray D Krahn, MD, MSc and Valeria E. Rac, MD, PhD.

Posted on August 14, 2015

The Canadian government invests $4.5 mln in the National Collaborative Hepatitis C Network, THETA – one of the research partners.

The World Hepatitis Day, July 28th, coincides with THETA announcement that Dr. Murray Krahn and Dr. William Wong, THETA co-investigators, are joining the team of more than 60 researchers, healthcare professionals and partners across Canada to work on a new National Collaborative Hepatitis C Network. From the July 27, 2015 official press release: "The National Collaborative Hepatitis C Network [will be] focused on improving the health of Canadians living with hepatitis C and preventing new infections. [The network] was funded through a partnership between the Canadian Institutes of Health Research and the Public Health Agency of Canada."

Congratulations to Dr Krahn and Dr Wong for being part of this important initiative!

Other press releases: The University of Montreal Hospital Research Centre (CRCHUM); CNW Newswire; Montreal Gazette;

Posted on July 28, 2015

HTX REACH issues its first “Call for Innovation”, offering funding to Ontario public healthcare delivery organizations to adopt innovative medical technologies.

In April, HTX.ca - The Health Technology Exchange established the new, HTX-led “REACH” Program (Resources for Evaluating, Adopting and Capitalizing on Innovative Healthcare Technology), supported by the Ontario Ministry of Government and Consumer Services (MGCS). The first “Call for Innovation” is being released July 10, 2015, with Expressions of Interest due August 17, 2015, and invited Full Proposals due September 28, 2015.  Public healthcare delivery organizations and medical technology innovation companies can click HERE for details on the HTX website.[...] Please see full Press Release HERE.

Posted on July 14, 2015

THETA presence at ISPOR conference

The ISPOR 20th Annual International Meeting will be held  in Philadelphia, Pennsylvania on May 16-20, 2015, and THETA's health economist Petros Pechlivanoglou , MSc, PhD will be there teaching one of the workshop sessions and delivering a podium presentation:

Extrapolating All-Cause Mortality Estimates in Economic Evaluations: A Simulation Analysis. Pechlivanoglou P, Abrahamyan L, Paulden M, Pham B, Krahn MD. Podium presentation: May 18, 2015, 2:15 PM - 3:15 PM

Surviving the Submission: Best Practices in Overall Survival Extrapolation In Oncology. Sanatan Shreay, PhD, Andrew Briggs, DPhil, MSc, Rachel Beckerman, PhD, Petros Pechlivanoglou , PhD. Workshops - Session III, May 19, 2015, 5:00 PM - 6:00 PM

 Posted May 7, 2015

THETA at Partners in Progress: BRIDGES Conference 2015

The TLC Team sparked great interest at the annual Partners in Progress: BRIDGES Conference 2015 with a poster presentation titled, "Complex Interventions for Comparative Effectiveness and Health Technology Assessment", authored by Dr. Valeria Rac and a THETA team of investigators. The poster outlined THETA's experience with the design, implementation and evaluation of complex interventions, such as the Wound Interdisciplinary Teams (WIT) study. The WIT study is ‎a complex community-based intervention focused on patients with chronic wounds.

A second poster, "Telehomecare for Patients with Heart Failure or Chronic Obstructive Pulmonary Disease: TeLeCare (TLC) Study", (same authors) was also presented. This poster highlighted  the preliminary findings of the qualitative study that is part of the Telehomecare  program evaluation study – TLC study. THETA research associates shared their experiences with the design, implementation and evaluation of complex interventions to date. They answered interesting questions about intervention ‎designs, evaluation framework selection, the important role of context in which a particular complex intervention is situated, and the role of different stakeholders (patients and their informal caregivers, health care providers, administrators and decision makers) in intervention implementation and adoption.
The interested parties noted that the findings from these studies could be relevant for other chronic disease interventions focused on improving the quality of patient care. Understanding for whom, and under what conditions complex interventions work, will allow for the development and enhancement of different programs and interventions that can alleviate the inappropriate over-utilization of health care resources.

Posted on April 21, 2015

CAHSPR conference 2015: Learning from Each Other: Across Disciplines, Jurisdictions and Generations

At the upcoming Canadian Association for Health Sevices and Policy Research (CAHSPR) Montreal Conference, from May 26 to 28 2015, discussions will focus on the following theme: Learning from Each Other: Across Disciplines, Jurisdictions and Generations. CAHSPR endeavours to facilitate the sharing of knowledge and approaches, particularly with regard to research and experiments, to guide the improvement of policies and practices.

Since the highest level of interaction between health regions, provinces and various leading countries has been built into the Program, hopefully this will drive vibrant exchanges among the many professions and scientific disciplines found under the umbrella of health. The conference will also provide a space for showcasing contrasting views held by various generations of men and women who work in the field, whether they are young and emerging or mid- to late-career, seasoned professionals.

2015 Conference description and photo adapted from CAHSPR website.

THETA staff is contributing several oral and poster presentations at the conference:

Oral Presentations

Cost-Utility Analysis of Robotic-Assisted versus Open Radical Prostatectomy in Patients with Clinically Localized Prostate Cancer in Ontario. Xie X, Abrahamyan L, Tawfik A, Kabali C, Pham B, Krahn M

Impact of Telehomecare on patients’ quality of life and disease-management skills.  Rac VE, Shahid N, Sahakyan Y, Fan I, Hunting G, Stanimirovic A, Petrosyan Y, Moneypenny C , Abrahamyan L, Pechlivanoglou P, Pham B, Mitsakakis N, Krahn M

Real-world effectiveness of stroke units in Ontario. A matched cohort analysis. Ieraci L, Pechlivanoglou P, Bayley M, Kapral M, Fang J, Li S, Krahn M

Procurement as an instrument of health policy: What are we asking, what can it do? Miller FA, Lehoux P, Barg C, Peacock S, Rac VE, Pham B, Krahn M

Poster Presentations

Structure and Function of Stroke Units in Ontario in 2013-2014. Rac VE, Sahakyan Y, Fan I, Ieraci L, Hall R, Kelloway L, van der Velde G, Kapral M, Bayley M, Krahn M

Design, Implementation and Evaluation of Complex Health Care Interventions in the Community. Rac VE, Abrahamyan L, Pechlivanoglou P, Shahid N, Wong J, Sahakyan Y, Fan I, Hunting G, Carcone S, Stanimirovic A, Petrosyan Y, Ryan W, Chung S, Pham B, Mitsakakis N, Krahn M.

Posted on March 25, 2015

128 enrolled and counting!

We are happy to announce that SIESTA Home Sleep Study has now over 100 participants enrolled.

We welcome our latest study site, Sleep & Apnea Assessment Unit in London Health Sciences Centre with Dr. Charlie George (Site Investigator) and Ms. Ruth Strapp (Research Manager).  Already busy enrolling at this site are Jennifer OGorman and Leila MacBean, Lawson Study Coordinators!  Big thanks to Nancy Farr (Kingston Sleep Disorders Laboratory’s Study Coordinator), Sanjana Hye (Hamilton Sleep Disorders Clinic’s Study Coordinator) and all those who are involved for all their hard work. 

BresoTec Inc and its product ApneaDx™   is one of the first three companies selected by the MaRS Excellence in Clinical Innovation and Technology Evaluation (“EXCITE”) program. Photo curtesy of BresoTec Inc.

Posted on March 20, 2015

Screening Canadians for hepatitis C infection could be cost-effective and save lives

Congratulations to William Wong, PhD, Decision Modeler at THETA and Assistant Professor at the Faculty of Pharmacy, University of Toronto, on his newest publication: Cost-effectiveness of screening for hepatitis C in Canada. CMAJ (Canadian Medical Association Journal) just published media release and CMAJ Twitter feed is already abuzz with this important news.


THETA contributes to the upcoming 2015 CADTH Symposium.

This year 2015 CADTH Symposium theme is “What does the evidence say? HTA to support policy and practice”; it is held at TCU Place in Saskatoon, SK on April 12 – 14, 2015. THETA staff substantial contribution includes workshops, oral and poster presentations as well as discussion panels.


Complex Interventions for Comparative Effectiveness and Health Technology Assessment. Valeria E. Rac, Lusine Abrahamyan and Murray D Krahn
This is an introductory-level workshop about complex interventions and their increasing role in the comparative effectiveness and health technology assessment research. The course provides theoretical frameworks and practical guidance for the design, implementation and evaluation of the complex interventions. Real world examples will be used throughout - April 12, 2015; 9:00 am - 12pm.

Issues in the analysis of healthcare cost data. Nicholas Mitsakakis, Petros Pechlivanoglou - April 12, 2015; 9:00 am - 12pm

Integrating NMA in economic evaluations. Petros PechlivanoglouNicholas Mitsakakis - April 12, 2015; 1:00 pm to 4:00 pm

Panel Sessions

Public policy in the post-interferon era: Can we afford to cure Hepatitis C?  Murray Krahn (moderator), William W.L. Wong, Alnoor Ramji, Kevin Wilson - April 13 from 11:00 am – 12:30 pm

Improving the Appraisal of Non-Drug Technologies: Revising the Ontario Decision Framework. Presenters: Murray Krahn, Fiona Miller, Ann-Sylvia BrookerValeria E Rac, (Moderator); Authors: Krahn M, Miller FA, Bayoumi A, Giacomini M, Goeree R, Wagner F, Winsor S, Schunemann H, van deVelde G, Pham B, Petersen S - April 14; 13:00 – 14:30 pm

Oral Presentations

Cost-effectiveness of a one-time national hepatitis C screening program: impact of a selective drug reimbursement policy. William W.L. Wong, Jordan Feld, Murray Krahn - April 14, 2015; 10:15 – 11:45 am

An alternative parameterization of Bayesian logistic hierarchical models for mixed treatment comparisons. Petros Pechlivanoglou - April 14, 2015; 10:15 – 11:45 am

Two solitudes: HTA and procurement as pathways to the adoption of health technologies. Miller A Fiona, Barg C, Krahn M, Lehoux P, Peacock S, Rac VE. - April 14; 10:15 – 11:45 am

Poster Presentations

All poster presentations will be held during the Welcome Reception on the evening of April 12.

Implementation challenges of a community-based pragmatic randomized controlled trial in wound care. Valeria E Rac, Josephine Wong, Nicholas Mitsakakis, Eva Haratsidis and Murray Krahn

Analysis of aggregate health care cost data using Bayesian mixed models. Nicholas Mitsakakis, George Tomlinson

Benefits of transformations in mapping health utilities. Nicholas Mitsakakis, Karen Bremner and Murray Krahn

Projecting mortality rates in Economic Evaluation: A simulation study. Petros Pechlivanoglou, Lusine Abrahamyan, Ba' Pham, Serena Hsu, Mike Paulden, Murray Krahn

Including the patient’s family in cost-effectiveness analysis of end-of-life interventions. Ba' Pham, Fowler R, P Tanuseputro, D Manuel, N Sikich, S Baidoobonso, P Pechlivanoglou, L Levin, D Guerriere, P Coyte, M Krahn

Pulmonary Rehabilitation for Post-Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Cost-Effectiveness and Budget Impact Analysis. Xuanqian Xie, Myra Wang, Alexis Schaink, Murray Krahn

Cost effectiveness analysis of islet transplantation in patients with Type 1 Diabetes Mellitus. Xuanqian Xie, Benjamin Rich, Nandini Dendukuri


THETA Collaborative presents at the upcoming Society for Medical Decision Making (SMDM) 2014 – 36th Annual North American Meeting. This year’s theme: Medical Decision Making Among Diverse Populations: Advancing Practice, Policy, and Science, October 18 - 22, 2014, Miami, FL.

SMDM 2014


Short Course

Complex Interventions for Comparative Effectiveness and Health Technology AssessmentValeria E. Rac, MD, PhD, Lusine Abrahamyan, MD, MPH,PhD and Murray D Krahn, MD, MSc.  

This is an introductory-level course about complex interventions and their increasing role in the comparative effectiveness and health technology assessment research. The course provides theoretical frameworks and practical guidance for the design, implementation and evaluation of the complex interventions. Real world examples will be used throughout.

Oral Presentations

Implementation Challenges of a Community-Based Pragmatic Randomized Controlled Trial in Wound Care. Josephine F Wong, MD, Valeria E. Rac, MD, PhD, Nicholas Mitsakakis, MSc, PhD, Eva Haratsidis, BSc, RN and Murray D. Krahn, MD, MSc. 

Analysis of Healthcare Costs in Patients with Acute Whiplash-Associated Disorders Using Zero-Adjusted Gamma Models. Shahriar Shams, MA, Lusine Abrahamyan, MD, MPH, PhD, Gabrielle van der Velde, DC, PhD and Nicholas Mitsakakis, MSc, PhD.

The Impact of Estimating Mortality Rates in Cost-Effectiveness Analysis: A Simulation StudyPetros Pechlivanoglou, PhD, Lusine Abrahamyan, MD, MPH, PhD, Ba' Pham, MSc, PhD (c), Mike Paulden, MA, MSc. and Murray D Krahn, MD, MSc. 

Poster Presentations

Cost-Effectiveness Analysis of Palliative Team Care for Patients Nearing End-Of-Life. Ba' Pham, MSc, PhD (c), Robert A. Fowler, MD, MSc, Peter Tanuseputro, MD, MHSc, Douglas Manuel, MD, MSc, Nancy Sikich, MSc, Shamara Baidoobonso, MSc, PhD, Petros Pechlivanoglou, PhD, Les Levin, MD, MSc and Murray D. Krahn, MD, MSc.

Cost-Effectiveness of Hepatitis B Virus Screening Before Adjuvant Chemotherapy in Patients with Early Stage Breast Cancer. William W. L. Wong, PhD, Lisa K. Hicks, MD, MSc, Hong Anh Tu, PhD, Murray D. Krahn, MD, MSc, Kathleen I. Pritchard, MD, MSc, Jordan J. Feld, MD, MPH and Kelvin Chan, MD, MSc.  

Cost-Effectiveness of Screening Hepatitis C in Canada. William W. L. Wong, PhD, Hong Anh Tu, PhD, Jordan J. Feld, MD, MPH, Tom Wong, MD, MPH and Murray D. Krahn, MD, MSc.  

Cost Effectiveness Analysis of Systematic Referral to Multidisciplinary Wound Care Teams in Ontario. Evidence from the Wound Interdisciplinary Teams (Wit) Trial. Mengzhu Jiang, MSc, Petros Pechlivanoglou, PhD, Josephine F Wong, MD, Nicholas Mitsakakis, MSc, PhD, Steven M. Carcone, MSc, Ba' Pham, MSc, PhD (c), Valeria E. Rac, MD, PhD and Murray D Krahn, MD, MSc.  

Wound Interdisciplinary Teams (Wit): A Community-Based Pragmatic Randomized Controlled Trial. Valeria E. Rac, MD PhD, Josephine Wong, MD, Nicholas Mitsakakis, MSc PhD, Petros Pechlivanoglou, PhD, Steven M. Carcone, MSc and Murray D. Krahn, MD, MSc.

For more information about this conference, please check SMDM website.

Posted on Aug 2014

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  • Cancer Care Ontario
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